| http://www.w3.org/ns/prov#value | - The exact role of RAGE in the pathogenesis of AD is not yet clearly known, but activation of RAGE by ligands that are closely linked to AD, including beta amyloid peptide (A??), AGEs, and S100 proteins, appears to trigger several signal transduction cascades leading to neuronal loss.Binding of AGEs and A?? to RAGE has been reported to stimulate activation of transcription factor NF-??B which in tu
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