| http://www.w3.org/ns/prov#value | - Accurate functional assays don???t exist for most genes (and are cumbersome and imperfect even for well-studied genes such as BRCA1; hence the large numbers of BRCA mutations ending up in the ???variants of uncertain significance??? category), so it will often be difficult, expensive or simply downright impossible to get a handle on the effects of a newly discovered variant on disease risk.
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