| http://www.w3.org/ns/prov#value | - ic overviewConclusionAcknowledgementsConflict of interestReferencesTo date, only viruses of the H1, H2, and H3 subtypes are known to have caused pandemics.[131] It has been estimated that there have been at least 13 pandemics in the last 500 years, including four virologically well-documented ones in the 20th century.[7, 10] Although the origin of the ???Spanish??? influenza pandemic (1917???1918)
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