| http://www.w3.org/ns/prov#value | - The HIFs are important in retinal vascular development in part by enhancing transcription of important angiogenic factors, such as VEGF, during physiologic hypoxia54,55 and by increasing apoptotic effects caused by RTP801.56 Reactive oxygen species can also regulate HIFs by increasing transcriptional activity even in normoxia (Figure 1),57 whereas HIF1?? is usually stabilized and transcriptionally
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